| Viernes
/ Friday 21 |
| 08:30
– 08:50 |
Recogida
de Acreditaciones / Registration |
| 08:50 |
Opening and welcome addresses:
Autoridades
Salvador Moncada
José A. Gutiérrez Fuentes
Why this symposium.
|
| MESA
/ SESSION 1 |
ALIMENTACIÓN Y ATEROSCLEROSIS
Moderador / Chairperson:
Luis Masana.
|
| 09:00 |
Hans Lithell
Professor (emer.) of Geriatrics. Uppsala University, Uppsala,
Sweden
|
|
Estilo de vida y aterosclerosis. Los estudios de
Uppsala. / Life Style and Atherosclerosis. The Uppsala
Studies.
Fifty year old men (n=2.322) were investigated in 1970-73.
All participants have been invited again every tenth
year. Cause of death and hospital care registries have
been followed. Risk factors for cardiovascular disease
were investigated. Insulin resistance was important
but was in its turn dependent on both exercise and food
patterns.
|
| 09:40 |
Emilio Ros
Head, Lipid Clinic, Nutrition & Dietetics Service,
Hospital Clínico, University of Barcelona, Barcelona,
Spain. |
|
Dieta: alimentos y riesgo cardiovascular
/ Whole foods and cardiovascular risk
Modern nutrition has evolved from advice against consuming
some foods solely to recommendations to include other
foods for beneficial health effects. In the last decade,
the results of long-term prospective studies have shown
that consumption of whole foods like fish, nuts, whole
cereals, legumes, alcoholic beverages, and tea is associated
with protection from atherosclerosis and its clinical
manifestations. Feeding trials that have investigated
the effects of these foods on surrogate markers of atherosclerosis,
such as blood lipids, insulin resistance, oxidized lipids,
or endothelial dysfunction have generally found measurable
benefits. However, clinical trial evidence of effects
on cardiovascular morbidity or mortality is scarce.
|
| 10:20 |
Eliseo Guallar
Assistant Professor. Department of Epidemiology and Welch
Center for Prevention, Epidemiology, and Clinical Research.
Johns Hopkins Medical Institutions. Baltimore, MD, USA |
|
Muerte súbita y consumo de aceite de pescado
/ Sudden death and fish oil consumption
El consumo de pescado es parte de las recomendaciones
para una dieta cardiosaludable. El consumo de pescado
proporciona ácidos grasos poli-insaturados n-3
de cadena muy larga (aceites de pescado) Aunque inicialmente
se pensaba que el principal efecto de estos aceites era
reducir la agregabilidad plaquetaria, modelos experimentales,
estudios epidemiológicos y ensayos clínicos
indican que los aceites de pescado pueden prevenir las
arritmias ventriculares y la muerte súbita. |
| 11:00 |
Frank B Hu
Associate Professor of Nutrition and Epidemiology.
Harvard School of Public Health, Boston, USA
|
|
Patrones dietéticos y enfermedad
coronaria / Dietary patterns and coronary heart disease
Numerous studies have examined individual nutrients or
foods in relation to risk of coronary heart disease (CHD).
Few studies, however, have examined the role of overall
dietary patterns in
Relation to CHD. Using the data from the Nurses' Health
Study and Health Professionals' Follow-up Study, we have
shown that major dietary patterns derived from factor
analysis are significant predictors of CHD in both men
and women. These patterns are also significantly related
to biomarkers of CHD, such as CRP, IL-6, ICAM-1, VCAM-1,
and E-selectin. These data underscore the importance of
overall dietary patterns in prevention of CHD.
|
| 11:30
– 12:00 |
Café / Coffee
|
| 12:00
– 13:00 |
SEMINARIOS (*)
|
| MESA
/ SESSION 2 |
ÓXIDO NÍTRICO Y ATEROSCLEROSIS
Moderador / Chairperson:
Miguel Pocoví
|
| 14:30 |
Fatima Bosch
Dept. Biochemistry and Molecular Biology School of Veterinary
Medicine and Gene Therapy.Universidad Autómoma
de Barcelona. Spain
|
|
Modelos Animales / Animal models
To determine the role of obesity in the development
of type 2 diabetes, we overexpressed PEPCK, a regulatory
enzyme of glyceroneogenesis in adipose tissue. These
animals developed obesity but did not become insulin
resistant. However, they develop diabetes when fed a
high fat diet. To counteract insulin resistance and
obesity, expression of genes involved in the control
of glucose uptake, such as glucokinase in skeletal muscle,
has been examined in high fat fed transgenic mice. These
models will be discussed.
|
| 15:10 |
Santiago Lamas
Investigador Científico del CSIC, Consejo Superior
de Investigaciones Científicas. Madrid, Spain.
|
|
Mecanismos de transducción de señales
de NO en el endotelio vascular / Vascular endothelium
NO signal transduction mechanisms
Implications of nitric oxide on the regulation of
endothelial cell migration and degradation of extracellular
matrix will be disscused. As the core of this presentation,
data in a model of wound healing describing the effects
of NO on collagenase-3 activation will be shown.
|
| 15:50 |
Helmut Drexler
Director Departament of Cardiology and Angiology.
Medizinische Hochschule Hannover, Hannover, Germany
|
|
Disfunción endotelial: papel
de la interleukina 6 en el remodelado y activación
de la placa vascular / Endothelial dysfunction: role of
interleukin 6 for vascular remodelling and plaque activation
Endothelial dysfunction plays an important role in cardiovascular
disease and is attributed to several mechanisms including
oxidative stress, inflammation and activation of the renin-angiotensin
system. This presentation outlines mechanisms and functional
consequences of endothelial dysfunction and inflammation
for vascular disease and arteriosclerosis |
| 16:30 |
Arnold Herman
Professor of Pharmacology, University of Antwerp, Belgium |
|
Terapias NO en aterosclerosis / NO therapies
in atherosclerosis
Rupture-prone atherosclerotic plaques contain numerous
macrophage-derived foam cells and few smooth muscle sells(SMC).Decreasing
the ratio between macrophages and SMC might favor plaque
stabilization.Macrophages expressing inducible nitric
oxide synthase become hypersensitive to killing by exogenous
NO donors.Treatment of cholesterol-fed rabbits with the
NO donor molsidomine increased the subendothelial macrophage-free
layer consisting mainly of SMC,and normalized both superoxide
production and superoxide dismutase expression.These findings
demonstrate that molsidomine decreases signs of oxidative
stress and increases features of stable atherosclerotic
plaques.
|
| 17:00
– 17:30 |
Café
/ Coffee |
| |
Conferencia
Moderador / Chairperson:
José A. Gutiérrez Fuentes
|
18:30 – 19:30
|
J Anthony Ware
Vice President, Cardiovascular Research and Clinical
Investigation, Eli Lilly and Company, USA
|
|
Reto ante la aterosclerosis / The challenge
ahead in atherosclerosis
Although many advances have occurred in the treatment
of atherosclerosis, the morbidity and mortality from this
disease are increasing. New therapies are needed to reduce
the risk of atherosclerosis to reduce the size of atherosclerotic
plaques, and to prevent ischemia in those with severe
disease. |
| 17:30
– 18:30 |
SEMINARIOS
(*) |
| Sábado
/ Saturday 22 |
| MESA
/ SESSION 3 |
DIAGNÓSTICO DEL RIESGO CARDIOVASCULAR
Moderador / Chairperson:
Fernando Fabiani
|
| 09:00 |
José Mª Ordovás
Professor Nutrition and Genetics at Tufts University.
Boston, USA |
|
Lipoproteínas residuales. Medición
y significado clínico / Residual lipoproteins.
Quantification and clinical significance
Postprandial lipid metabolism has received considerable
attention since it was shown that postprandial triglyceride-rich
lipoproteins are involved in the development of atherosclerosis.
The interindividual differences in postprandial lipid
metabolism are dramatic and they are in part due to genetic
factors that could be used in the near future for better
prediction of cardiovascular risk.
|
| 09:40 |
Ann Rumley
Departament of Medicine, Haemostasis, Thrombosis &
Vascular Medicine Section, University of Glasgow, Glasgow,
UK
|
|
Dímero D y enfermedad coronaria / D-dimer
and coronary heart disease
Fibrin D-dimer, a marker of cross-linked fibrin turnover,
is now routinely used in the diagnosis of clinically suspected
venous thromboembolism. Over the past 10 years, we have
evaluated the predictive value of plasma D-dimer (within
the population range) for CHD and stroke. A meta-analysis
of prospective CHD studies showed a significant, independent
association with risk. 3 recent studies have also shown
that D-dimer is an independent predictor of stroke. |
| 10:20 |
Juan A. Gómez Gerique
Director. Servicio de Bioquímica Clínica,
FJD-UNILABS, Madrid, España |
|
Proteína C Reactiva
como marcador de riesgo coronario / C reactive protein
as a coronary risk marker
La proteína C reactiva un clásico marcador
de inflamación aguda, está emergiendo como
un potente predictor de accidentes cardiovasculares. La
elevación moderada de la concentración de
PCR parece indicar un estado de inflamación de
bajo grado, característico del proceso de arteriosclerosis.
Por otra parte, las estatinas, fármacos que son
capaces de disminuir significativamente la incidencia
de accidentes cardiovasculares, también son capaces
de hacer disminuir las concentraciones de PCR. En esta
ponencia revisaremos la información disponible
por el momento. |
|
11:00
|
Arnold von Eckardstein
Director and Professor of Clinical Chemistry, Institute
of Clinical Chemistry, University Hospital of Zurich,
Zurich, Switzerland |
|
Efectos antiaterógenos del HDL
/ Antiatherogenic effects of HDL
Low HDL cholesterol is an important independent cardiovascular
risk factor, which contributes to the estimation of global
CHD risk by scores and algorithms. HDL and its protein
and lipid components exert a broad scope of potentially
antiatherogenic effects, which make them an interesting
target for anti-atherogenic therapy.
|
| 11:30
– 12:00 |
Café
/ Coffee |
12:00
– 13:00
|
SEMINARIOS (*) |
| |
Conferencia de Clausura
Moderador / Chairperson:
José A. Gutiérrez Fuentes
|
| 13:00 – 14:00 |
Salvador Moncada
Director of The Wolfson Institute for Biomedical Research,
University College London, UK
|
|
El óxido nítrico:¿amigo
o enemigo? / Nitric oxide: friend or foe?
Nitric oxide is a physiological activator of guanylate
cyclase. In addition, it inhibits cytochrome c oxidase
in a reversible manner and in competition with oxygen.
It is likely that this effect has a significance physiological
relevance and also has pathophysio-logical implications.
|
| |
|
| (*) SEMINARIOS |
| SEMINARIO 1 |
 |
Miguel A. Rubio
Unidad de Nutrición y Dietética. Hospital
Clínico San Carlos, Madrid, España.
|
|
Alimentación y ECV: aproximación práctica
en prevención primaria y secundaria / Nutrition
and CVD: practical approach in primary and secondary
prevention
Descripción de la relación de los ácidos
grasos con el metabolismo lipídico.
Descripción de alimentos con diferente riqueza
en ácidos grasos cardioprotectores y antioxidantes.
Diseño genérico de una dieta cardioprotectora.
Normas alimentarias para la prevención primaria
y secundaria.
Ejercicios prácticos.
|
| SEMINARIO
2 |
|
Pedro González Santos
Head of Department of Internal Medicine. University
Hospital. University of Malaga. Spain
|
Sindrome Metabólico y ECV:
abordaje práctico / Metabolic syndrome and CVD:
practical approach
Obesity and insulin resistance are often associated with
hyperinsulinemia, glucose intolerance, hypertension, dyslipidemia
and premature atherosclerosis. This cluster of abnormalities,
known as the metabolic syndrome, has been assessed and
incorporated into the guidelines of the NCEP- Adult Panel
III.
We will discusses the effect of genetic and environmental
factors, the link of visceral adiposity and insulin
resistance to vascular disease, and the data on the
pathophysiology and treatment of metabolic syndrome.
|
| SEMINARIO
3 |
|
Leocadio Rodríguez Mañas*
y Juan A. Gómez Gerique
*Geriatra. Hospital Universitario de Getafe, Madrid,
España
|
| Guías Clínicas y valoración
del riesgo cardiovascular en el anciano / Guidelines
and cardiovascular risk evaluation in the elderly
El papel que cada uno de los factores clásicos
y emergentes de riesgo cardiovascular ejercen en el
desencadenamiento de enfermedades cardiovasculares y
la potenciación de sus respectivos efectos cuando
se agrupan en un mismo individuo, han llevado a las
autoridades sanitarias y grupos científicos de
referencia a recomendar la valoración global
del riesgo cardiovascular, en función del cual
se determinan las actitudes diagnósticas y terapéuticas.
No obstante, los métodos hoy vigentes ofrecen
algunas debilidades que se comentaran.
|
| SEMINARIO
4 |
|
Agustín Gómez de la
Cámara
Head. Clinical Epidemiology Research Unit. 12 de
Octubre Hospital, Madrid, Spain
|
| Información al paciente y
cumplimiento terapéutico / Information to patients
and therapeutical accomplishment
The degree of hypercholesterolemia control among
treated patients is poor. There is no enough data explaining
this situation. Several causes could be involved, mainly
related to physicians attitude and patient compliance.
Information exchange may improve this reality.
|
| Viernes
21 |
Sábado
22 |
| 12:00
a 13:00 |
17:30
a 18:30 |
|
|
| |
|
